Early Amniocentesis Versus Transabdominal Chorionic Villus Sampling for Early Invasive Prenatal Diagnosis: A 15-Year Prospective Cohort Study

Background

Two sampling routes are available when definitive genetic testing is required in the first trimester: early amniocentesis (EA) and transabdominal chorionic villus sampling (TA-CVS). Direct comparisons of the two at 11 to 14 weeks of gestation are, however, few. Our aim was to place the techniques side by side in terms of the genetic information they yield, the chromosomal abnormalities they uncover and the pregnancy outcomes that follow them.