Current Issues in Molecular Biology
Follistatin-Like Protein 1 Contributes to Acute Traumatic Spinal Cord Injury by Enhancing Neuroinflammation Through the Modulation of Interferon Regulatory Factor 5-Mediated Macrophage Activation
By Yixing Luo, Shaozhou Ni, Lü Peng and 4 others.
Abstract
Background and Purpose: Follistatin-like protein 1 (Fstl1) is a secreted glycoprotein with context-dependent inflammatory activity. We investigated whether Fstl1 is a reproducible feature of traumatic spinal cord injury (SCI) and whether it regulates macrophage activation through interferon regulatory factor 5 (IRF5).