Children
Role of Synaptosomal-Associated Protein 25 Gene in Clinical Response to Methylphenidate Among Turkish Pediatric ADHD Cohort
By Zeynep Gizem Todurga Seven, Kübra Çiğdem Pekkoç-Uyanık, Muhammet Fatih Akdemir and 5 others.
Abstract
Introduction
Methylphenidate (MPH) is a first-line treatment for attention-deficit/hyperactivity disorder (ADHD). MPH blocks dopamine and norepinephrine transporters, increasing synaptic catecholamine levels. Neurotransmitter release depends on presynaptic vesicle docking and fusion mediated by synaptosomal-associated protein 25 kDa (SNAP-25), a target-soluble NSF attachment protein receptor (SNARE) protein encoded by the SNAP-25 gene. This study aimed to investigate whether genetic variations in the SNAP-25 gene contribute to variability in clinical response to MPH in pediatric patients with ADHD.
