Cells
The Dual Roles of Esophageal Submucosal Glands: Protection and Pathogenesis in Benign and Malignant Disease: A Scoping Review
By Chun‐Ting Chen, Michiel F.G. de Maat, Ann L. C. Driessen and 5 others.
Abstract
Background
Esophageal submucosal glands (SMGs) contribute to mucosal defense through bicarbonate, mucin, and reparative-factor secretion. Chronic reflux may impair these functions and remodel the glandular compartment, potentially linking SMG injury to reflux esophagitis, Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC).
