Siponimod Induces Peripheral T Cell Redistribution Without Affecting Glial Cells or Behavior in Naïve Mice

Background

Siponimod is a selective modulator of sphingosine-1-phosphate receptors 1 and 5, approved for the treatment of secondary progressive multiple sclerosis. Apart from its immunomodulatory effects, it has been proposed to exert pro-regenerative and pro-myelinating effects. However, it is unclear whether the reported neuroprotective and pro-regenerative effects of siponimod reflect direct engagement on glial cells or arise secondary to reduced neuroinflammation.