Lack of Association Between CAT rs1001179 and SOD2 rs4880 Variants and Risk for Multiple Sclerosis

Objectives

Several lines of evidence point to a potential involvement of oxidative stress in the pathophysiology of multiple sclerosis (MS). Superoxide dismutase isoenzymes 1 and 2 (SOD1 and SOD2) and catalase (CAT) are key components of the enzymatic antioxidant defense system. Consequently, genetic variation in the genes encoding these enzymes may influence susceptibility to MS. However, previous studies examining the relationship between SOD1, SOD2, and CAT variants and MS susceptibility have yielded inconsistent findings. The present study aimed to investigate whether two common single-nucleotide variants (SNVs) in CAT and SOD2 are associated with MS risk in a Caucasian Spanish population.