Kocatepe Veterinary Journal
Evaluation of the Efficacy of Quercetin Against DNA, Lipid, and Protein Damage in a Diabetic Rat Model
By Ahmet Büyükben, Funda Kargın Kıral and Selim Sekkin.
Abstract
Diabetes Mellitus (DM) induces oxidative stress, causing severe biomolecular damage. This study investigated quercetin's protective effects against protein, DNA, and lipid oxidation in streptozotocin (STZ)-induced diabetic rats. Rats received STZ (50 mg.kg-1, i.p.) and were treated with quercetin (20, 50, or 70 mg.kg-1, daily, orally) for 21 days. Malondialdehyde (MDA), advanced oxidation protein products (AOPP), nitrotyrosine (NT), and protein carbonyl content (PCC) were measured, alongside lymphocyte Comet assays. STZ significantly elevated MDA levels compared to controls, but all quercetin treatments effectively reduced MDA concentrations (p
Keywords
- Natural Antidiabetic Agents Studies
- Malondialdehyde
- Quercetin
- Streptozotocin
- Oxidative damage
- Nitrotyrosine
- Rat model
- Comet assay
- Diabetes mellitus
- Open access
Source
Published in Kocatepe Veterinary Journal. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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