China National GeneBank DataBase
Single-cell B-cell receptor repertoires associated with SARS-CoV-2 immune imprinting
By 牛潇(Xiao Niu).
Abstract
This project contains 10x Genomics single-cell V(D)J sequencing data from JN.1 RBD-reactive memory B cells collected from Chinese adult cohorts with distinct levels of ancestral SARS-CoV-2 immune imprinting. The dataset supports analyses of immunoglobulin gene usage, B-cell clonotypes, and antibody repertoire features associated with the severity of immune imprinting and neutralization of the BA.3.2.2 variant.
Keywords
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2
- immune imprinting
- memory B cells
- B cell receptor repertoire
- V(D)J recombination
- B cell clonotypes
- neutralizing antibodies
- Omicron variant
- COVID-19 severity
- single-cell sequencing
- Open access
Source
Published in China National GeneBank DataBase. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.