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International Journal of Medical Toxicology and Forensic Medicine
By Ruqaya Jumaa Khaleel, Waleed Ghanim and Muhsin S.G. Al-Mozie.
This study investigated the potential protective effects of fisetin and coenzyme Q10 (CoQ10), administered individually or in combination, against cyclophosphamide (CP)-associated renal injury in rats.
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Forty rats were allocated into five groups: Group 1 received the corresponding vehicles (1% DMSO and 0.5 mL of corn oil) and intraperitoneal (IP) normal saline; Group 2 received the corresponding vehicles plus CP via a single IP injection at 150 mg/kg; Group 3 received CoQ10 (100 mg/kg) dissolved in corn oil, together with 1% DMSO as a separate vehicle, and CP. Group 4 received fisetin (20 mg/kg) prepared in 1% DMSO/glycerin, together with corn oil administered separately as a vehicle, and CP. Group 5 received CoQ10 (100 mg/kg), fisetin (20 mg/kg), and CP. Treatments were administered orally once daily for 21 consecutive days. On day 17, the designated oral treatment was administered before a single IP injection of CP (150 mg/kg), and oral treatments were continued daily for the remaining four days (days 18–21).
Exposure to a toxic dose of CP significantly increased serum β2-microglobulin levels (ng/mL). Caspase-3 (ng/mL) and urea (mg/dL) levels increased, whereas creatinine (mg/dL) levels did not change significantly; TAC (U/mL) significantly decreased; and histopathological alterations occurred. Treatment with CoQ10 or fisetin alone improved several biochemical parameters and histopathological alterations, whereas the combination provided less protection than either individual treatment.
CoQ10 and fisetin individually showed nephroprotective effects against CP-induced renal injury, whereas their combination provided less protection under the conditions tested.
Published in International Journal of Medical Toxicology and Forensic Medicine. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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