Urologia Internationalis
The Role of Phosphodiesterase Inhibitors in Acute Renal Colic: A Systematic Review and Meta-analysis
By Alhasan Altayf, Hashem Altabbaa, Mohamed R. Ezz and 3 others.
Abstract
Introduction
Acute renal colic is a common and intensely painful condition, primarily managed with non-steroidal anti-inflammatory drugs (NSAIDs). However, NSAIDs carry risks of gastrointestinal, renal, and cardiovascular adverse events. Phosphodiesterase (PDE) inhibitors, which promote ureteral smooth muscle relaxation, may offer an alternative for selected patients. This systematic review and meta-analysis assessed the efficacy and safety of PDE inhibitors compared with NSAIDs or placebo in acute renal colic.