Infection and Drug Resistance
A Novel Erg3 T208Is Substitution Associated with Reduced Fluconazole and Voriconazole Susceptibility in Clinical Talaromyces marneffei Isolates from HIV/AIDS Patients
By Yanqing Zheng, Pang Xiaofeng, Fang Yinmei and 4 others.
Abstract
Introduction
Talaromyces marneffei ( T. marneffei ) is a life-threatening dimorphic fungus endemic to southern China and Southeast Asia. Decreased triazole susceptibility in T. marneffei has emerged as a major clinical challenge for treating immunocompromised patients, particularly those living with HIV/AIDS. This study aimed to explore the mechanisms underlying reduced susceptibility to fluconazole and voriconazole in T. marneffei isolates derived from HIV/AIDS patients in China.