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Anti-obesity potential of a latex-derived bioactive peptide fraction from Calotropis procera: Depot-selective fat reduction and systemic metabolic improvement in high-fat diet-fed mice
By Gaban S, Ramos M, de Alencar NMN and 1 others.
Abstract
Abstract BACKGROUND: This study investigated the effects of the latex protein fraction (LP) from Calotropis procera (Ait.) R.Br. on body weight, food intake, fat deposition, organ weight, and plasma inflammatory and metabolic markers in male Swiss mice fed a high-fat diet (HFD).
Methods
Thirty mice were divided into four groups: normal diet (ND), HFD, HFD plus LP 5 mg/kg (LP5), and HFD plus LP 50 mg/kg (LP50), administered intraperitoneally every 4 days during the final 6 weeks of a 27-week protocol.
