Exploring human bromodomain-containing protein 2 (BRD2) genetic variants in juvenile myoclonic epilepsy (JME): Insights from genetic and gene enrichment analysis

Abstract Purpose: Juvenile myoclonic epilepsy (JME) is a common subtype of genetic generalized epilepsy characterized by myoclonic jerks, generalized tonic–clonic seizures, and occasional absence seizures. Although several susceptibility genes have been implicated in JME, the contribution of coding variants within the bromodomain-containing protein 2 (BRD2) gene remain inadequately understood . This study investigates genetic variants within exon 13 of the Bromodomain Containing Protein-2 (BRD2) gene in juvenile myoclonic epilepsy (JME) patients.