Preprints.org
Case Series Analysis of Five Rare Cases of Hyperprolactinemia in Diabetes Mellitus: Clinical Characteristics, Molecular Pathways, and Implications for Targeted Management
By El-Nagar AA, Kenawy AM and Karam M.
Abstract
Background
Hyperprolactinemia, characterized by serum prolactin levels >20 ng/mL, is a rare comorbidity in diabetes mellitus, potentially exacerbating insulin resistance and glycemic dysregulation via JAK/STAT signaling. This case series analysis examines five rare cases to elucidate clinical patterns, molecular mechanisms, and therapeutic outcomes, aiming to inform precision endocrine management.
