Design and Characterization of Cu(II), Ni(II), and Co(II) Complexes with 5-Carboxy-2-Thiouracil: Spectroscopic, Antimicrobial and Cytotoxic Studies

The aim of this paper is to obtain and verify the structures and the biological activity of novel metal complexes derived from 5-carboxy-2-thiouracil. The paper outlines a synthesis method and assesses the antimicrobial activity of newly formed Cu(II), Ni(II) and Co(II) complexes. Several syntheses were carried out with and without NaOH. The structural were verified by melting point analysis, ICP-OES for Cu, Ni and Co, UV-Vis, ATR, solid state and solution 1H NMR, 13C NMR spectroscopy. In addition, the antimi-crobial activity of these complexes and the free ligand are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. For the cytotoxic assay we were used the HCT-116 colorectal cell line (ATCC). Only two Ni(II) complexes show reduction in the number of viable tumor cells. All the other compounds did not lead to a significant reduction in the number of viable cells as determined by one-way ANOVA statistical analysis.