Preprints.org
Molecular Profile and Antiviral Resistance of Hepatitis B and Human Immunodeficiency Viruses in Patients from an Army Conflict-Affected Region, South Kivu Province, Democratic Republic of Congo
By Basimane Bisimwa P, Shindano Akilimali T, Mbo Mukonkole JP and 7 others.
Abstract
Background
This study characterized HBV and HIV molecular profiles and drug resistance mutations in South Kivu, DRC.
Methods
A cross-sectional study included 3,421 participants aged 18–70 years. Serological testing was performed using ELISA, and viral loads (VL) were quantified by GeneXpert. Molecular analyses involved 132 HBV-positive and 383 HIV-positive samples. Nucleic acids were extracted using QIAamp® MiniElute®. HBV genotyping was performed by PCR, and HIV-1 sequencing using the Viroseq® system.