Preprints.org
Trained Immunity in Sickle Cell Disease: From Hemolytic Inflammation to Therapeutic Reprogramming
By Oladimeji FD, Fashanu TM, Oladimeji FC and 4 others.
Abstract
Background
Sickle cell disease (SCD) is a condition of persistent inflammation and coagulation that includes both haemolysis, vaso-occlusion and organ damage result from this interplay. However, does not by itself, account for the variation in disease severity among individuals.
Objectives
To examine whether trained immunity can be a potential mechanistic framework connecting chronic haemolysis to the long-term vaso-inflammatory activity in SCD, and therapeutic implications as well as knowledge gaps.