Journal of Ophthalmic and Vision Research
The Effect of Adjunctive Mitomycin C on Outcomes of Phaco-Viscocanalostomy in Glaucoma: A Randomized Controlled Trial
By Saeed Shokoohi-Rad, Akram Karimi and Elham Bakhtiari.
Abstract
Purpose
To evaluate whether adjunctive intraoperative mitomycin C (MMC) improves intraocular pressure (IOP) control, visual acuity, or medication burden in patients undergoing phacoviscocanalostomy for moderate to advanced open-angle glaucoma.
Methods
This double-masked, parallel-group randomized clinical trial included 92 eyes of 92 patients with medically uncontrolled open-angle glaucoma, who were randomly assigned to undergo phaco-viscocanalostomy with (n = 46) or without (n = 46) adjunctive MMC (0.02% for 90 seconds). Outcomes including IOP, best-corrected visual acuity (BCVA), cup-to-disc ratio (C/D), and number of glaucoma medications were assessed at baseline, 1 week, and 1, 3, and 6 months postoperatively.