The state of the microbial community of the periodontal pocket around implants in hiv-infected patients on the background of receiving antiretroviral therapy

Subject. The state of the microbial community in the periodontal pocket around implants in HIV-infected patients. Objectives. To assess the state of the microbial community in the periodontal pocket around implants in HIV-infected patients receiving antiretroviral therapy. Methodology. Microbial communities of the periodontal pocket around implants were compared in healthy controls and in HIV-infected patients receiving antiretroviral therapy using Roche 454 sequencing and RT-PCR. Results. An analysis of the state of the microbial community of the periodontal pocket of an implant in HIV-infected patients while receiving antiretroviral therapy based on the results of sequenced data alignment showed the presence of 7 types of bacteria at the level of the taxonomic "type" of biological species. Among them, Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria account for more than 90 % of the total number of bacterial types. In patients living without HIV infection, the presence of 7 types of bacteria with a similar proportion was revealed. The differences between the groups at this classification level were not statistically significant. At the "genus" level, a total of 28 bacterial genera were identified in the microbial community of the periodontal pocket of the implant in HIV-infected patients while taking HAART, while 34 bacterial genera were identified in patients living without HIV infection. Conclusion. An assessment of the microbial community of the periodontal pocket around implants in HIV-infected patients receiving antiretroviral therapy revealed that the microbial community of the periodontal pocket around implants in HIV-infected patients who underwent dental implantation while receiving antiretroviral therapy is similar in generic and typical distribution to the group of patients living without HIV infection. Representatives of the genus Streptococcus (type Firmicutes) and the genus Veillonella (type Firmicutes) are predominant, the presence of which is characteristic of the normal microflora of the oral cavity.