Apollo
Exploratory analysis of continuous glucose monitoring patterns in first degree relatives with dysglycemia at risk of progression to stage 3 type 1 diabetes
By Maria Loredana Marcovecchio.
Abstract
Introduction
Continuous glucose monitoring (CGM) can characterize subtle glucose changes in early-stage type 1 diabetes (T1D). We assessed whether CGM metrics predict Stage 3 T1D in first-degree relatives (FDRs) with positive islet autoantibodies (IAb) and dysglycemia participating in INNODIA.
Methods
We analysed IAb-positive FDRs with dysglycemia and available CGM data. CGM metrics were analyzed longitudinally and in a restricted analysis limited to the last assessment before Stage 3 T1D in progressors. CGM metrics were compared using linear mixed models. Predictive performance of single and combined CGM metrics models was evaluated using ROC analyses.
