Principles of pharmacotherapy in pediatric patients: fundamental pharmacological and pharmacokinetic knowledge and its applicability

This review article offers a comprehensive overview of the fundamental principles underpinning the management of pharmacotherapy in pediatric patients. Recognizing the distinct pharmacological and pharmacokinetic attributes of children is imperative for the safe and efficacious administration of drugs. By exploring critical concepts encompassing drug absorption, distribution, metabolism, and excretion within pediatric populations, healthcare providers can inform decisions when prescribing medications for children across all the age groups. Additionally, the implementation of pharmacokinetic/pharmacodynamic (PK/PD) principles in clinical practice assumes paramount importance in tailoring drug regimens to suit individual pediatric patients, thereby optimizing therapeutic outcomes and mitigating the potential for adverse events. As the landscape of pediatric pharmacotherapy research continues to advance, it is essential for healthcare professionals to remain up to date with the latest developments to ensure the provision of optimal care for this vulnerable patient demographic.