Quantitative Relationship Between Lumipulse G Measures of pTau217 in Plasma and the Temporal Cortex

Phosphorylated tau217 (pTau217) plasma assays have shown high diagnostic accuracy for Alzheimer disease (AD). However, validation of plasma pTau217 as a direct marker of brain-based pTau pathology requires understanding of its quantitative relationship with cortical pTau217. The primary objective of this postmortem validation study was to determine the quantitative relationship of plasma pTau217 levels and the pTau217/β-amyloid (Aβ)1–42 ratio with cortical pTau217 levels measured using Lumipulse G immunoassays.