New-Generation Antiseizure Medications: Who Takes the Lead in the Real World?

Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy Cerulli Irelli E, Roberti R, Sole Borioni M, Anzellotti F, Belcastro V, Beretta S, Boero G, Bonanni P, Chiesa V, D’Aniello A, Dainese F, Deleo F, DeMaria G, DiGennaro G, DiGennaro G, Didato G, Dono F, Falcicchio G, Ferlazzo E, Fortunato F, LaNeve A, Mecarelli O, Montalenti E, Morano A, Nilo A, Operto F, Paladin F, Pascarella A, Pauletto G, Pietrafusa N, Pignatta P, Pulitano P, Renna R, Rosati E, Sammarra I, DiBonaventura C, Russo E, Lattanzi S; for the Comparative REal-World Evidence (CREW) Study Group. JAMA Neurol . 2026 Apr 1;83(4):320–328.