Medical Principles and Practice
Clinical Significance of Klotho, Fibroblast Growth Factor 23, and their Ratio for Acute Kidney Injury in Sepsis Patients
By Sumian Dou, Yuchao Shen, Botao Zhao and 7 others.
Abstract
Objective
The sepsis-associated acute kidney injury (SA-AKI) is common in patients with sepsis and associated with poor outcomes, yet serum creatinine and urine output have limited value for early assessment. We examined whether admission Klotho, fibroblast growth factor 23 (FGF23), and the Klotho/FGF23 ratio were associated with SA-AKI and short-term outcomes and compared their discriminative performance.