Case report of high stage cortical sparing CTE in a retired NFL player with frontal hypometabolism and progressive cognitive behavioral decline

Introduction

Chronic traumatic encephalopathy (CTE) appears to represent a pathological outcome of significant repetitive head impact exposure. Although increasing clinicopathologic studies have characterized features of CTE during life, longitudinal prospective characterization integrating neuropsychological, neuroimaging, and neuropathological findings remains limited.