Reproductive Phenotypes and Assisted Reproductive Outcomes in Vietnamese Men With 47,XYY: A Retrospective Cohort Study

Objective

This study aimed to describe the clinical characteristics, reproductive function, and reproductive outcomes of men with a 47,XYY karyotype. Materials and Methods: This retrospective study was conducted at the Andrology and Fertility Hospital of Hanoi, Vietnam. The cohort included 22 men: 21 with non-mosaic 47,XYY and one with mosaic 46,XY/47,XYY. Data included semen analyses, reproductive hormone profiles, sexual function assessments using the International Index of Erectile Function and Premature Ejaculation Diagnostic Tool (PEDT), microdissection testicular sperm extraction and testicular histology findings, and reproductive outcomes after natural conception or assisted reproductive technology (ART).