Immunity, inflammation and disease
Dynamic Shifts in Lymphocyte Subsets During the Menopausal Transition and Sexual Dimorphism in Immunosenescence
By Xuan C, He L, Bohan Z and 3 others.
Abstract
Background
Immunosenescence demonstrates marked sexual dimorphism, yet the dynamic changes in lymphocyte subsets across the female menopausal transition are poorly defined. This study characterized these age- and sex-related immune variations in a large Chinese cohort.
Methods
In this cross-sectional study, we analyzed 4209 healthy adults using flow cytometry to quantify lymphocyte subsets and PD-1 expression. Females were stratified by age and reproductive stage. Sex comparisons were performed after propensity score age-matching.
