EP8.85 Evaluating the Performance of PROMIS Global-10 Compared with Legacy Instruments in Patients Undergoing Bernese Periacetabular Osteotomy

Abstract Background The Patient-Reported Outcomes Measurement Information System (PROMIS) Global-10 is a patient-reported outcome measure (PROM) designed to assess overall physical and mental health. Its utility for evaluating hip-specific outcomes in patients undergoing Bernese periacetabular osteotomy (PAO) remains to be validated. Methods Patients who underwent Bernese PAO by a single surgeon between June 2020 and January 2024 and completed PROMIS Global-10 along with legacy hip-specific PROMs, including Hip Disability and Osteoarthritis Outcome Score (HOOS) and the 12-Item International Hip Outcome Tool (iHOT-12), at ≥1-year follow-up were included. Floor and ceiling effects were assessed for all measures. Spearman’s rank correlation evaluated associations between PROMIS Global-10 components and legacy PROMs. For PROMIS components with strong correlations, minimal clinically important difference (MCID) was calculated using distribution methods, while patient acceptable symptom state (PASS) and absolute substantial clinical benefit (SCB) thresholds were determined using anchor-based methods. Results Eighty-one patients met inclusion criteria. Significant improvements were observed from baseline in PROMIS Global-10 Physical and Mental scores (P<0.001), as well as all legacy PROMs (P<0.001). Preoperatively, no significant floor or ceiling effects were identified across measures. Postoperatively, ceiling effects were present in several legacy PROMs (HOOS Symptoms 18.5%, Pain 25.9%, Activities of Daily Living 49.4%, Sports 16.1%, iHOT-12 16.1%), but not in the PROMIS Mental component (14.8%) or Physical component (8.6%). The PROMIS Physical component demonstrated moderate to strong correlations with legacy PROMs (ρ=0.633–0.766), whereas the Mental component showed negligible to weak correlations (ρ=0.234–0.350). For the Physical component, MCID, PASS, and SCB thresholds were 4.9, 46.9, and 48.1, respectively, with excellent receiver operating characteristic curve performance for PASS (AUROC=0.963) and good performance for SCB (AUROC=0.821). Achievement rates were 67.1% (MCID), 71.6% (PASS), and 58.0% (SCB). Conclusion The PROMIS Global-10 Physical component is a responsive measure for assessing outcomes after PAO, demonstrating strong correlation with established hip-specific PROMs and no significant ceiling effects postoperatively. In contrast, the Mental component shows limited association with hip-specific outcomes. PROMIS Global-10 Physical may serve as an efficient, generalizable alternative to legacy hip PROMs in this population.