npj Aging
Vascular memory and the erasability spectrum: reframing reversible and irreversible vascular aging
By Rooban Sivakumar, K. A. Arul Senghor and Vinodhini M.
Abstract
Vascular aging integrates cardiometabolic stress into persistent molecular, cellular, and structural injury, yet its variable reversibility remains poorly explained. We propose a vascular memory framework in which prior stress is stored across epigenetic, immune, mitochondrial-redox, senescent, and matrix substrates and recalled as vascular dysfunction. Their differing erasability may guide provisional endotyping and therapeutic selection, distinguish modifiable from persistent injury, and emphasize earlier, substrate-matched intervention before consolidation limits reversibility.
Keywords
- Nitric Oxide and Endothelin Effects
- Vascular disease
- Vascular smooth muscle
- Vascular occlusion
- Vascular dementia
- ATHEROSCLEROTIC VASCULAR DISEASE
- Stress (linguistics)
- Consolidation (business)
- Open access
Source
Published in npj Aging. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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