Longitudinal Analysis of the Association Between Urinary Dickkopf-Related Protein 3 and Kidney Allograft Function in Kidney Transplant Recipients: Findings From the TransplantLines Biobank and Cohort Study

Kidney transplantation is the preferred treatment for patients with kidney failure. However, even after successful transplantation, kidney transplant recipients (KTR) remain at risk of graft failure, with tubular injury being one of the significant contributing factors.1 Previously, urinary Dickkopf-related protein 3 (uDKK3), a stress-induced tubular cell-derived profibrotic glycoprotein, was shown to be associated with tubulointerstitial fibrosis and worse kidney function in patients with chronic kidney disease and KTR.