Photodiagnosis and Photodynamic Therapy
Association of static and dynamic pupillary abnormalities with retinal microvasculopathy and neurodegeneration in diabetics
By Yan Guo, Yanxi Xie, Lei Dong and 4 others.
Abstract
Purpose
To investigate the characteristics of pupillary statics and dynamics and explore the relationship between pupillary abnormalities and microvascular as well as neurodegenerative changes of retina in the early stages of diabetes.
Methods
This cross-sectional observational study included forty-eight diabetic subjects without diabetic retinopathy (NDR group), thirty-nine diabetic subjects with mild or moderate non proliferative diabetic retinopathy (DR group), and forty age- and sex-matched healthy adults (control group). Pupil size and pupillary light reflex were measured monocularly using a PLR-3000 dynamic pupillometer, and OCT/OCTA scans were acquired with a Van Gogh SS-OCTA device in all three groups.
