Osteoarthritis and Cartilage Open
Serum leptin, adiposity, and their link to symptomatic hand osteoarthritis in individuals with radiological signs – A cross-sectional HALLOA cohort study
By Malin Zimmerman, Noemi Raman, Margareta Törnblom and 2 others.
Abstract
Objective
To investigate the relationship between serum leptin levels and symptomatic hand osteoarthritis (OA) in individuals with radiographically confirmed hand OA.
Method
This cross-sectional study included 90 individuals with radiographically confirmed hand OA. Symptomatic hand OA was diagnosed according to the American College of Rheumatology (ACR) criteria. Serum leptin levels, body mass index (BMI), and bioimpedance were measured. Participants reported pain intensity in the Numeric Rating Scale (NRS), self-reported upper-extremity disability (QuickDASH), number of bodily pain sites, and underwent pain pressure threshold (PPT) and grip strength measurements. Characteristics were compared between individuals with and without symptomatic hand OA. Binary logistic regressions were used to investigate the relationship between serum leptin levels and symptomatic hand OA. Adjustments were made stepwise for 1. age and sex, 2. adiposity, 3. radiographic severity of hand OA, and 4. PPT.