Journal of Infection and Public Health
A novel
By Hanyu Fu, Zihe Zhou, Zhiheng Tang and 7 others.
Abstract
Background
Bacteriophages represent a promising alternative for combating carbapenem-resistant hypervirulent Klebsiella pneumoniae (Kp). However, the molecular mechanisms underlying phage-host co-evolution and the action of phage-derived anti-virulence effectors remain insufficiently explored. We hypothesized that a novel Przondovirus phage could suppress Kp virulence through receptor-mediated evolutionary trade-offs and disruption of metabolic pathways.