Urology Case Reports
Donor-derived bladder cancer following kidney transplantation
By Eric A. Engels, Sandra Burkett, V.Krishnan Ramanujan and 4 others.
Abstract
Kidney transplantation is associated with elevated cancer risk. We report a 75- year-old woman diagnosed with bladder cancer five years after receiving a kidney transplant from a male donor. Whole genome sequencing of this tumor revealed many DNA reads that mapped to the Y chromosome, and fluorescent in situ hybridization identified that 32% of tumor cells had a Y chromosome. These results support a donor origin of this cancer, with the most plausible source being the urothelium of the donor allograft. Sequencing also identified BK polyomavirus, which likely contributed to the development of this cancer.
Keywords
- Bladder and Urothelial Cancer Treatments
- kidney transplantation
- post-transplant malignancy
- Open access
Source
Published in Urology Case Reports. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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