Chinese Journal of Traumatology
Evaluation of teriparatide as a promoter of mandibular fracture healing: An observational clinical study
By Trishala Annamalai Rajan, Elavenil Panneerselvam, Akshaya Subhashinee Dhanasekaran and 1 others.
Abstract
Purpose
The objective of this study was to evaluate the role of teriparatide in promoting mandibular fracture healing.
Methods
In this prospective cohort study, 12 patients belonging to American Society of Anesthesiologists status II, who required open reduction and internal fixation of mandibular fractures were categorized into exposure group 9 (52.94%) fractures and non-exposure group 8 (47.06%) fractures. Following open reduction and internal fixation, patients in the exposure group were administered 28.2 μg of teriparatide subcutaneously, twice a week for 4 weeks, while the non-exposure group did not receive any treatment. The groups were followed up and reviewed for a period of 6 weeks to assess fracture healing. The primary outcome parameters were postoperative pain, levels of serum osteocalcin and pro collagen type 1 N-terminal propeptide (P1NP) and bone density on CT. The secondary outcome parameters were requirement of analgesics and mouth opening. Pain was assessed using numerical pain rating scale. Serum osteocalcin and P1NP were assessed pre-operatively and on the 30th post-operative day. Bone density was assessed pre-operatively and on the 6th post-operative week. The data was analyzed for descriptive and analytical statistics (comparison of means and proportions). To analyze the data SPSS (IBM SPSS Statistics for Windows, Version 26.0, Armonk, NY: IBM Corp. Released 2019) is used. Significance level is fixed as 5% (α = 0.05).
