Comparison of Postoperative Pain Intensity after Laparoscopic Cholecystectomy with Intraperitoneal Injection of Bupivacaine or Hydrocortisone alone Versus Bupivacaine with Morphine: A Clinical Trial

Background and Aim: Laparoscopic cholecystectomy is used as a standard method for gallbladder resection due to less pain and bleeding than open surgery. This study was performed to evaluate and compare the severity of pain after laparoscopic cholecystectomy with the intraperitoneal injection of bupivacaine or hydrocortisone alone or bupivacaine with morphine in the 5th Azar educational hospital in Gorgan in 2015. Materials and Methods: This randomized double-blind clinical trial study was performed on 60 patients undergoing laparoscopic cholecystectomy surgery. Patients were divided into 3 groups: A (30 cc of bupivacaine 0.25% intraperitoneal), B (30 cc of bupivacaine 0.25% with 2 mg morphine intraperitoneal), and C (200 mg hydrocortisone at 30 cc). The severity of pain and hemodynamic parameters were registered at specific times 30 minutes, 1, 4 hours after surgery. Data were analyzed using ANOVA, independent t-test, and chi-square in SPSS 18 software.