Role of Denosumab in Chronic Kidney Disease with Paget’s Disease of Bone: A Case Report and Review of Literature

Introduction

Paget’s disease of bone (PDB) is rarely encountered in patients with chronic kidney disease (CKD), with limited reports in the literature. The coexistence of these conditions poses significant diagnostic and therapeutic challenges. This case report examines the management of PDB in advanced CKD, where standard bisphosphonate therapy is contraindicated. Case Report: We report a 51-year-old male with CKD stage 5 presenting with bone pain, deformity, and fracture. Imaging and biochemical evaluation confirmed the diagnosis of Paget’s disease. Due to contraindications to bisphosphonates, the patient was treated with denosumab. The patient showed initial symptomatic and biochemical improvement; however, recurred after 4 months, requiring repeated doses.