American Society of Clinical Oncology
WBC Growth Factors: ASCO Guideline Update
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Abstract
To update the ASCO guideline on use of hematopoietic colony-stimulating factors (CSFs) in patients with cancer.
A systematic review identified randomized controlled trials (RCTs), meta-analyses, and systematic reviews that addressed use of CSFs for the prevention or treatment of neutropenic events, or for mobilization of stem cells, in adults with cancer. PubMed and the Cochrane Library were searched for articles published from September 1, 2014, to August 22, 2025. ASCO convened an Expert Panel to review the evidence and formulate recommendations.
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