International Federation of Clinical Chemistry
Validation of an enzyme calibrator--an IFCC guideline. International Federation of Clinical Chemistry
Abstract
The objective of this guideline is to improve standardization in clinical enzymology in order to improve intermethod comparability of patients' results.
The reference system, combination of the reference method and the reference material, is used to produce a reference value for a given catalytic activity. Sets of methods are formed of methods exhibiting the same analytical specificity. Materials intended to be used as enzyme calibrators are experimentally checked for their commutability.
The transfer of accuracy from the reference value to patients' results is dependent on methods (analytical specificity) and on materials (experimentally assessed commutability). The feasibility of this approach was demonstrated with materials of high level for several enzymes and for each of them for several routine methods.
Expected advantages of this approach in clinical enzymology are presented.
Source and rights
Published by Clinical biochemistry, 1998. The guideline itself is at the source linked here.
Prognia summarises this guideline for reference and education. It is not medical advice. Always check the official guideline and current local protocols before acting on it.
At a glance
- Organisation
- International Federation of Clinical Chemistry
- Published
- 1998
- Applies to
- 🌐 International
- Scope
- Regional
- Journal
- Clinical biochemistry