National College of Hospital Biochemistry
Management of HIL indices in clinical biochemistry: A position statement from the National College of Hospital Biochemistry
Abstract
The management of HIL indices (Hemolysis, Icterus, Lipemia) remains heterogeneous among clinical chemistry laboratories, despite their major impact on result interpretation. Based on recommendations from the IFCC and the EFLM, a review of the literature, and expert opinions, the French Collège National de Biochimie des Hôpitaux (CNBH) proposes in this document a structured framework aimed at harmonizing practices. These recommendations address the three phases of the total testing process: (1) pre-analytical measures intended to prevent interferences related to sample collection, transport, and preparation; (2) analytical guidelines to better understand the limitations of measurement methods, strengthen quality control, and secure the interpretation of HIL indices; and (3) a standardized post-analytical strategy integrating the definition of thresholds based on potential clinical impact and harmonized communication of results. This document aims to support laboratory professionals in rationalizing and securing the management of HIL indices, thereby improving result quality and clinical management.
Source and rights
Published by Annales de biologie clinique, 2026. The guideline itself is at the source linked here.
Prognia summarises this guideline for reference and education. It is not medical advice. Always check the official guideline and current local protocols before acting on it.
At a glance
- Organisation
- National College of Hospital Biochemistry
- Published
- 2026
- Applies to
- 🇫🇷 France
- Scope
- National