International Stereotactic Radiosurgery Society
International Stereotactic Radiosurgery Society (ISRS) practice guidelines for radiosurgery in recurrent high-grade glioma
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Abstract
Recurrence invariably occurs in patients with high-grade glioma (HGG) despite maximal definitive therapy. Currently, there is no standard-of-care salvage treatment approach and re-irradiation is considered an option for select patients. Various radiotherapy fractionation schedules have been investigated, including the use of stereotactic radiosurgery (SRS). The aim of this study was to provide clinical practice recommendations on behalf of the International Stereotactic Radiosurgery Society (ISRS) specific to salvage SRS for recurrent-HGG. We define SRS as focal radiation in a single fraction and hypofractionated radiosurgery (HFSRS) as focal radiation delivered over 2-5 fractions.
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