ESTRO clinical practice guideline on radiotherapy for adult soft tissue sarcoma of the extremities and trunk wall - Endorsed by ASTRO.

This updated clinical practice guideline provides a practical, evidence-based approach for the management of adult soft tissue sarcoma of the extremity and trunk wall.

The European Society for Radiotherapy and Oncology (ESTRO) formed a task force of 13 European experts, alongside 3 experts from the American Society for Radiation Oncology (ASTRO), to analyze current evidence, provide recommendations and establish expert consensus in areas lacking strong evidence. Thirteen key questions were identified, encompassing indications for radiotherapy, pre- vs. postoperative radiotherapy, treatment preparation, patient positioning, target volume delineation, dose and fractionation, adverse events assessment, and dose guidance for organs of interest. Key recommendations were formulated and tabulated for each topic, addressing all identified key questions.