Diagnostic approach and treatment paradigm in atrophic age related macular degeneration: Recommendations of the France Macula Federation

Atrophic age-related macular degeneration (AMD) represents a detrimental progression of age-related maculopathy, characterized by advanced retinal lesions associated with drusen and pseudodrusen as well as alterations in the outer retinal layers and RPE. It is characterized by a thinning of the neuroretinal tissue linked to the disappearance of the outer layers of the retina and the RPE. Our goal is to offer to ophthalmologists recommendations in the diagnosis and management of atrophic AMD with a standardized approach, in order to facilitate and optimize the management of this disease. The diagnosis of atrophic AMD is based on multimodal imaging; color fundus photography, autofluorescence images of the fundus (AFF) and structural optical coherence tomography (OCT) are the first-line examinations to assess lesion size and foveolar sparing. OCT-angiography (OCT-A) is useful in diagnosing associated choroidal neovascularization. At times, the differential diagnosis will require other complementary examinations, such as fluorescein and/or indocyanine green angiography. The assessment of visual function is essentially based on the measurement of visual acuity; other functional tests such as reading speed, measurement of visual acuity in low luminance (LLVA), contrast sensitivity or microperimetry are of definite interest, but are not yet used in routine clinical practice. The therapeutic solutions for this pathology are multidisciplinary; they combine regular clinical monitoring, medical treatment, psychological support, orthoptic rehabilitation and optical visual aids. Support groups are of significant benefit.

Published by Journal francais d'ophtalmologie, 2025. The guideline itself is at the source linked here.

doi.org/10.1016/j.jfo.2025.104473