2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

To develop updated guidelines for the pharmacologic management of rheumatoid arthritis.

We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising clinicians and patients achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations.