Néphrologie
Estimated Glomerular Filtration Rate — CKD-EPI 2021 Equation
Débit de filtration glomérulaire estimé sans variable ethnique.
Contenu en anglais
Calculateur DFGe (CKD-EPI 2021)
Résultat
91.7mL/min/1.73m²
G1 — Normal
Comment l’utiliser
- 1
Saisir la créatininémie (mg/dL). Jeûne non requis. Une maladie aiguë peut abaisser transitoirement le DFGe.
- 2
Âge et sexe. Le CKD-EPI 2021 supprime la variable ethnique, conformément au groupe de travail conjoint NKF/ASN.
- 3
La stadification de la MRC nécessite deux valeurs à ≥3 mois d’intervalle. Un DFGe bas isolé peut correspondre à une IRA.
Quand l’utiliser
Calculate eGFR in all patients with potential CKD, diabetes, hypertension, or heart failure. Essential for drug dosing decisions. Required before initiating or continuing metformin, SGLT2 inhibitors, NOACs, low-molecular-weight heparin, and many nephrotoxic agents.
- Diagnostic et stadification de la MRC
- DFGe + rapport albuminurie/créatininurie définissent le stade de MRC (KDIGO 2024).
- Posologie des médicaments
- La plupart des adaptations posologiques rénales se réfèrent au DFGe.
- Sécurité des produits de contraste
- DFGe < 30 : avis néphrologique avant un scanner injecté.
À propos du score
The estimated Glomerular Filtration Rate (eGFR) using the 2021 CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation is the standard method for assessing kidney function in clinical practice worldwide. The 2021 equation removed race as a variable from the original 2009 CKD-EPI formula to improve equity in CKD staging and organ transplant eligibility. eGFR is the cornerstone of KDIGO CKD staging, guides dosage adjustments for renally cleared drugs (including NOACs, antibiotics, and metformin), and determines eligibility for SGLT2 inhibitors — which are now indicated for CKD regardless of diabetes status per KDIGO 2024 guidelines.
Questions fréquentes
What is a normal eGFR level?
An eGFR ≥90 mL/min/1.73m² is considered normal kidney function (KDIGO G1 stage). Values of 60–89 represent mildly decreased function (G2). CKD is defined as eGFR <60 mL/min/1.73m² or evidence of kidney damage (such as proteinuria or haematuria) persisting for >3 months. A single low value may reflect acute injury rather than CKD.
When should I refer to nephrology based on eGFR?
KDIGO recommends nephrology referral for eGFR <30 mL/min/1.73m² (G4–G5), or for eGFR 30–44 (G3b) with a rapid rate of decline, significant proteinuria, or difficult-to-manage complications. Earlier referral (eGFR 45–59) is warranted if there are concerns about underlying cause or trajectory.
