Case Report: Contezolid-containing regimens for disseminated Bacillus Calmette-Guérin disease in three children with primary immunodeficiency

Introduction

Disseminated Bacillus Calmette-Guérin (BCG) disease is a rare but life-threatening complication in children with primary immunodeficiency (PID). Linezolid (LZD) is effective but limited by myelosuppression. Contezolid (CZD), a novel oxazolidinone, has shown better hematological safety in adults, but pediatric data are scarce. This retrospective case series aims to provide real-world experience on CZD use in this challenging population.