Frontiers in microbiology
Genetic organization and mobile-element basis of β-lactam resistance in a polyclonal respiratory Haemophilus influenzae population
Por Xu X, Luo Y, Tan J y 3 más.
Contenido en inglés
Resumen
Background
Haemophilus influenzae is an important respiratory colonizer and opportunistic pathogen. In the post-Hib vaccine era, non-type b and nontypeable strains have become increasingly associated with clinical disease, while β-lactam resistance complicates treatment and surveillance.
Methods
To investigate the genetic basis and dissemination of β-lactam resistance, we performed comparative whole-genome analysis of 65 respiratory H. influenzae isolates from sputum and bronchial lavage fluid. The collection showed a highly polyclonal structure, including 28 known sequence types and 12 unassigned isolates.