Differential Modulation of WNT/β-Catenin Pathway-Associated Molecular Responses by Palmitate and Oleate in Lipid-Loaded HepG2 Cells

Background

Palmitate (PA) and oleate (OA), the predominant saturated and monounsaturated fatty acids, respectively, may differentially influence hepatic signaling. However, their individual and combined effects on WNT/β-catenin-related responses in HepG2 cells remain incompletely characterized.

Methods