Efficacy and Safety of Safinamide as an Adjunct to Levodopa for Motor Fluctuations in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background

Motor fluctuations often occur with long-term levodopa treatment in Parkinson's disease (PD). Safinamide is a drug that inhibits monoamine oxidase B (MAO-B) and modulates glutamate. It is used together with levodopa. A summary of the latest evidence is needed to assess its effectiveness and safety.