Inflammatory burden index predicts arteriogenic erectile dysfunction: a mediation analysis involving the TyG index

Introduction

Inflammation and metabolic dysregulation play important roles in the pathophysiology of erectile dysfunction. The inflammatory burden index (IBI), a composite biomarker integrating C-reactive protein (CRP), neutrophils, and lymphocytes, has emerged as a marker of systemic inflammatory load. However, the association between IBI and arteriogenic erectile dysfunction (AED) remains largely unexplored. To investigate the association between IBI and AED and to examine whether insulin resistance (IR), assessed by the triglyceride-glucose (TyG) index, mediates this relationship.